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Sekine S*, Sekine Y.

OMA1 clears traffic jam in TOM tunnel in mammals.

J Cell Biol. 2024 May 6;223(5):e202403190. PMID: 38619450

*Corresponding author

Sekine Y#, Houston R#, Eckl EM, Fessler E, Narendra DP, Jae LT, and Sekine S*.

A mitochondrial iron-responsive pathway regulated by DELE1.

Mol Cell. 2023 June 15;83(12):2059-2076.e6. PMID: 37327776

#co-first author,*Corresponding author

Akabane S, Watanabe K, Nishino K, Yamashita S, Kosako H, Kato M, Sekine S, Kanki T, Matsuda N, Endo T, and Oka T.

TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.

Cell Reports. 2023 May 30;42(5):112454. PMID: 37160114 

Houston R, Sekine Y, Larsen MB, Murakami K, Mullet SJ, Wendell SG, Narendra DP, Chen BB, and Sekine S*.

Discovery of bactericides as an acute mitochondrial membrane damage inducer.

Mol Biol Cell. 2021 Nov 1;32(21):ar32. PMID: 34495738 *Corresponding author

Li H, Frankenfield AM, Houston R, Sekine S, Hao L.

Thiol-Cleavable Biotin for Chemical and Enzymatic Biotinylation and Its Application to Mitochondrial TurboID Proteomics.

J Am Soc Mass Spectrom. 2021 Sep 1;32(9):2358-2365. PMID: 33909971

Sekine Y, Houston R, Sekine S.

Cellular metabolic stress responses via organelles.

Exp Cell Res. 2021 Mar 1;400(1):112515. PMID: 33582095 

Houston R, Sekine S, Calderon MJ, Seifuddin F, Wang G, Kawagishi H, Malide DS, Li Y, Gucek M, Pirooznia M, Nelson AJ, Stokes MP, Ornstein JS, Mullett SJ, Wendell SG, Watkins SC, Finkel T and Sekine Y.

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses.

PLoS Biol. 2020 Nov 30; 18(11) PMID:33253182

Houston R, Sekine S, Sekine Y.

The Coupling of Translational Control and Stress Responses.

J Biochem. 2020 Aug 1; 168(2):93-102.  PMID: 32484875


Liu YT, Huang X, Nguyen D, Shammas M, Wu B, Dombi E, Springer DA, Poulton J, Sekine S, Narendra DP.

Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.

Hum Mol Genet. 2020 Jun 3;29(9):1547-1567 PMID:32338760


Sugawara S, Kanamaru Y, Sekine S, Maekawa L, Takahashi A, Yamamoto T, Watanabe K, Fujisawa T, Hattori K, Ichijo H.

The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1.

J Biol Chem. 2020 Apr 24;295(17):5588-5601 PMID:32144202

Sekine S*.

PINK1 import regulation at a crossroad of mitochondrial fate: the molecular mechanisms of PINK1 import.

J Biochem. 2020 Mar 1;167(3):217-224. PMID:31504668 *Corresponding author


Sekine S, Wang C, Sideris DP, Bunker E, Zhang Z, Youle RJ.

Reciprocal roles of Tom7 and OMA1 during mitochondrial import and activation of PINK1.

Mol Cell. 2019 March 7; 73(5):1028-1043 PMID: 30733118

Sekine S, Youle RJ.

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol.

BMC Biol. 2018 Jan 10; 16(1):2. PMID: 29325568

Sekine S*.

Mitochondrial proteolysis and its roles in stress responses.

Nihon Yakurigaku Zasshi. 2017;149(6):264-268. PMID: 28626118 *Corresponding author


Burman JL, Pickles S, Wang C, Sekine S, Vargas JNS, Zhang Z, Youle AM, Nezich CL, Wu X, Hammer JA, Youle RJ.

Mitochondrial fission facilitates the selective mitophagy of protein aggregates.

J Cell Biol. 2017 Oct 2; 216(10):3231-3247 PMID: 28893839


Chaikuad A, Filippakopoulos P, Marcsisin SR, Picaud S, Schröder M, Sekine S, Ichijo H, Engen JR, Takeda K, Knapp S.

Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.

Structure. 2017 Jul 5;25(7):1089-1099.e3. PMID: 28648608


Yamaguchi N, Sekine S, Naguro I, Sekine Y, Ichijo H.

KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation.

PLoS One. 2016 Sep 15; 11(9):e0163118. PMID: 27631783


Sekine S#, Yao A#, Hattori K, Sugawara S, Naguro I, Koike M, Uchiyama Y, Takeda K, Ichijo H.

The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress.

EBioMedicine. 2016 Jan 29; 5:82-92. PMID: 27077115

#co-first author


Watanabe T, Sekine S, Naguro I, Sekine Y, Ichijo H.

Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis.

J Biol Chem. 2015 Apr 24; 290(17):10791-803. PMID: 25752609

Sekine S, Ichijo H.

Mitochondrial proteolysis: its emerging roles in stress responses.

Biochim Biophys Acta. 2015 Feb;1850(2):274-80. PMID: 25459516


Sekine S, Kanamaru Y, Koike M, Nishihara A, Okada M, Kinoshita H, Kamiyama M, Maruyama J, Uchiyama Y, Ishihara N, Takeda K, Ichijo H.

Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.

J Biol Chem. 2012 Oct 5; 287(41):34635-45. PMID: 22915595

Kanamaru Y, Sekine S, Ichijo H, Takeda K.

The phosphorylation-dependent regulation of mitochondrial proteins in stress responses.

J Signal Transduct. 2012; 2012:931215. PMID: 22848813


Takeda K, Komuro Y, Hayakawa T, Oguchi H, Ishida Y, Murakami S, Noguchi T, Kinoshita H, Sekine Y, Iemura S, Natsume T, Ichijo H.

Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12301-5. PMID: 1590015

Murakami S, Noguchi T, Takeda K, Ichijo H.

Stress signaling in cancer.

Cancer Sci. 2007 Oct; 98(10):15217.


Osaka N, Takahashi T, Murakami S, Matsuzawa A, Noguchi T, Fujiwara T, Aburatani H, Moriyama K, Takeda K, Ichijo H.

ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds.

J. Cell Biol. 2007 Mar 26; 176(7):903-9.



関根史織、関根悠介「Lab Report 海外ラボ独立編、アメリカでの独立奮闘記:夫婦二人三脚でのラボ立ち上げ」

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実験医学増刊号:in vivo実験医学によるヒト疾患解明の最前線(羊土社)30 (2), 229-235, (2012)

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